Susana Mandel
Florida International University
Psoriasis impact in quality of life
Psoriasis is a disease with a chronic development in which well demarcated plaques with erythema and silvery scales are present on the skin. This is the result of interactions between immunological and factortic factors that can be triggered by the environment (McCance, 2010; Green, 2011). Nails, scalp and joints can also be involved. Psoriasis is considered severe when 10% or more of the body scratch is affected, and when hands and feet are involved, because it interferes with activities of daily living (Gelfand, 2004). It is estimated that more than 3% of the American population suffers from psoriasis (National Institute of Arthritis and Musculoeskeletal and Skin Diseases, 2009). Diseases that occur with psoriasis hold cardiovascular disease, inflammatory bowel disease, diabetes, and lymphoma (Menter, 2008). Psoriasis is a large caper for the normal functioning of daily living for more than 60% of individuals with the disease (National Psoriasis Fundation, n.d.).
Psoriasis results from an altered regulation of inflammation due to supernormal activation of T-cells and a genetic predisposition (Menter, 2008).
The chromosomal loci determine in psoriasis are the PSOR I-VIII. PSOR I (HLA-CW6 allele) is the major susceptibility gene for psoriasis. Drugs, skin trauma, stress, and infection are important triggers of the disease (Menter, 2008). T-cells disclose interferon gamma and interleukins (6, 12, 15, 17, 22 and 23) and tumor necrosis factor (TNF) by and by they are activated (McCance, 2010). Inflammation of the lesions set up keratinocytes that educate in the basal layer to hyperproliferate and continue the disease body process (Menter, 2008). The fast proliferation of the cells does not permit time for the cells to mature and keratinization to occur, resulting in a thick epidermis. The silvery scales are the clinical manifestation of...If you want to get a full essay, erect it on our website: Orderessay
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