The Department of Pharmacology & Toxicology

It criticizes the fact that the principles used to esteem other pharmacotherapies have largely been ignored in rate to marijuana, and there are no well-controlled studies of its use using bar therapies as positive controls, or studies examining the use of checkup exam exam examination marijuana in patients unresponsive to other medications. Most studies rely either on self-reports or on physician's case studies.

Martin points to the need to lam out further studies of the safety of marijuana use because, although it has non been shown to have inauspicious effects on young and salubrious people, this may not be the case with patients who are light or an at-risk population. Long-term inhalation of marijuana has been shown to have adverse effects on the lungs, mess suppress the immune system, and can lead to withdrawal symptoms on cessation of use. Impairment of cognitive function has been reported in long-term, heavy cannabis use.

However, medical marijuana most likely has some efficacy, says Martin, because its primary active voice ingredient is D9-tetrahydrocannabinol (

THC), which has been carefully evaluated and sanction for clinical use. The question, he says, is whether the oral solve of THC - dronabinol - is a suitable substitute for smoked marijuana. The oral preparation is archetype when long duration is needed, such as when used to chip delayed-onset nausea and vomiting (i.e.

in chemotherapy) and for treating protracted pain, but the fast onset of effects gained by smoking marijuana may be more applicable in other medical situations. He notes that research is currently underway to develop an inhaled form of THC which would obviate the need for smoking marijuana.

The author presents a well-balanced, knowledgeable, and well-researched paper, published in a highly respected medical journal, with information from reliable sources. He does not try to turn the reader one way or the other, but besides presents the facts and offers his suggestions that further in-depth research be carried to accurately assess the viability of the medical use of marijuana.

In this paper, Martin uses highly reputable international citation sources for his information, such as WHO, the National Institutes for Health, the
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